Convergent regional brain abnormalities in behavioral variant frontotemporal dementia: A neuroimaging meta‐analysis of 73 studies

ABSTRACT: Abstract

Introduction

Numerous studies have reported brain alterations in behavioral variant frontotemporal dementia (bvFTD). However, they pointed to inconsistent findings.

Methods

We used a meta‐analytic approach to identify the convergent structural and functional brain abnormalities in bvFTD. Following current best‐practice neuroimaging meta‐analysis guidelines, we searched PubMed and Embase databases and performed reference tracking. Then, the coordinates of group comparisons between bvFTD and controls from 73 studies were extracted and tested for convergence using activation likelihood estimation.

Results

We identified convergent abnormalities in the anterior cingulate cortices, anterior insula, amygdala, paracingulate, striatum, and hippocampus. Task‐based

SUBMITTER: Kamalian A 

PROVIDER: S-EPMC9148620 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature