PpGpp and cytotoxicity diversity in Shiga toxin-producing Escherichia coli (STEC) isolates.

ABSTRACT: Shiga toxin-producing Escherichia coli (STEC) is a known food pathogen, which main reservoir is the intestine of ruminants. The abundance of different STEC lineages in nature reflect a heterogeneity that is characterised by the differential expression of certain genotypic characteristics, which in turn are influenced by the environmental conditions to which the microorganism is exposed. Bacterial homeostasis and stress response are under the control of the alarmone guanosine tetraphosphate (ppGpp), which intrinsic levels varies across the E. coli species. In the present study, 50 STEC isolates from healthy sheep were evaluated regarding their ppGpp content, cytotoxicity and other relevant genetic and phenotypic characteristics. We found that the level of ppGpp and cytotoxicity varied consi

SUBMITTER: Stella AE 

PROVIDER: S-EPMC9148826 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature