HTR1A Gene Polymorphism in Type 2 Diabetes Mellitus Comorbid with Major Depressive Disorder in a Chinese Population.

ABSTRACT:

Background

Major depressive disorder is a frequent mental illness, which is common in patients with type 2 diabetes. Type 2 diabetes comorbid with depression has a worse prognosis. There are multiple risk factors for depression, and genetic studies have shown that gene polymorphism may play an important role in the pathogenesis of depression.

Methods

A total of 874 patients with type 2 diabetes were recruited for this study and divided into two groups: depressive group (DDM group, n = 234) and non-depressive group (NDDM group, n = 640). HTR1A gene polymorphisms (rs6295, rs878567, rs1800044) genotyping work was performed using a custom by design 48-Plex SNPscan^TM Kit.

Results

The rs6295, rs878567, and rs1800044 SNPs were not associated with type 2 diabetes c

SUBMITTER: Simayi D 

PROVIDER: S-EPMC9148918 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature