Staphylococcus aureus specific lung resident memory CD4⁺ Th1 cells attenuate the severity of influenza virus induced secondary bacterial pneumonia.

ABSTRACT: Staphylococcus aureus is a major cause of severe pulmonary infections. The evolution of multi-drug resistant strains limits antibiotic treatment options. To date, all candidate vaccines tested have failed, highlighting the need for an increased understanding of the immunological requirements for effective S. aureus immunity. Using an S. aureus strain engineered to express a trackable CD4⁺ T cell epitope and a murine model of S. aureus pneumonia, we show strategies that lodge Th1 polarised bacterium specific CD4⁺ tissue resident memory T cells (Trm) in the lung can significantly attenuate the severity of S. aureus pneumonia. This contrasts natural infection of mice that fails to lodge CD4⁺ Trm cells along the respiratory tract or provide protection against r

SUBMITTER: Braverman J 

PROVIDER: S-EPMC9148937 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature