Co-Expression of TIGIT and Helios Marks Immunosenescent CD8⁺ T Cells During Aging.

ABSTRACT: Aging leads to alterations in the immune system that result in ineffective responsiveness against pathogens. Features of this process, collectively known as immunosenescence, accumulate in CD8⁺ T cells with age and have been ascribed to differentiation of these cells during the course of life. Here we aimed to identify novel markers in CD8⁺ T cells associated with immunosenescence. Furthermore, we assessed how these markers relate to the aging-related accumulation of highly differentiated CD27^-CD28^- cells. We found that co-expression of the transcription factor Helios and the aging-related marker TIGIT identifies CD8⁺ T cells that fail to proliferate and show impaired induction of activation markers CD69 and CD25 in response to stimula

SUBMITTER: Pieren DKJ 

PROVIDER: S-EPMC9148977 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature