Role of MicroRNAs in acceleration of vascular endothelial senescence.

ABSTRACT:

Backgrounds

Many factors are involved in cellular aging, and senescence induction requires complex regulation of various signaling networks and processes. Specifically, in the area of aging-related vascular cognitive impairment, laboratory-based findings have not yet yielded agents of practical use for clinical settings. One possible reason is that the physiologic elements of aging have been insufficiently considered. We sought to establish techniques to better model cellular aging using modulation of microRNAs, aiming to identify key microRNAs capable of fine-tuning aging-associated genes, and thereby regulating the senescence of vascular endothelial cells.

Methods

We utilized expression microRNA arrays to evaluate control and senescent vascular endothelial cells in order t

SUBMITTER: Toyama K 

PROVIDER: S-EPMC9149016 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature