Effects of a novel form of intraoperative radiation therapy on quality of life among patients with early-stage breast cancer.

ABSTRACT:

Purpose

To investigate patient-perceived quality of life (QOL) among patients treated with a novel form of breast intraoperative radiation therapy (PB-IORT).

Methods and materials

Patients treated with PB-IORT as part of a phase II clinical trial from 2013 to 2020 were identified. Patients were given the European Organization for Research and Treatment of Cancer (EORTC) core 30-item Quality of Life Questionnaire (QLQ-C30) encompassing global health, functionality, and symptomatology at baseline, 1-month, 6-months, 12-months, and 24-months after PB-IORT. Scores were on a 100-point scale with change greater than 10 considered clinically significant. Scores at interval follow-up were compared to baseline using repeated measure modeling with an unstructured covariance matrix.

SUBMITTER: Lattimore CM 

PROVIDER: S-EPMC9149037 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature