The long-term impact of elevated C-reactive protein levels during pregnancy on brain morphology in late childhood.

ABSTRACT:

Importance

Animal studies show that Maternal Immune Activation (MIA) may have detrimental effects on fetal brain development. Clinical studies provide evidence for structural brain abnormalities in human neonates following MIA, but no study has investigated the long-term effects of MIA (as measured with biomarkers) on human brain morphology ten years after the exposure.

Objective

Our aim was to evaluate the long-term impact of MIA on brain morphology in 10-year-old children, including the possible mediating role of gestational age at birth.

Design

We leveraged data from Generation R, a large-scale prospective pregnancy cohort study. Pregnant women were included between 2002 and 2006, and their children were invited to participate in the MRI study between 2013 and 2015

SUBMITTER: Suleri A 

PROVIDER: S-EPMC9149104 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature