Individual differences in threat and reward neural circuitry activation: Testing dimensional models of early adversity, anxiety and depression.

ABSTRACT: Altered functioning of the brain's threat and reward circuitry has been linked to early life adversity and to symptoms of anxiety and depression. To date, however, these relationships have been studied largely in isolation and in categorical-based approaches. It is unclear to what extent early life adversity and psychopathology have unique effects on brain functioning during threat and reward processing. We examined functional brain activity during a face processing task in threat (amygdala and ventromedial prefrontal cortex) and reward (ventral striatum and orbitofrontal cortex) regions of interest among a sample (N = 103) of young adults (aged 18-19 years) in relation to dimensional measures of early life adversity and symptoms of anxiety and depression. Results demonstrated a significan

SUBMITTER: Young KS 

PROVIDER: S-EPMC9149108 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature