Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells.

ABSTRACT:

Background

Perivascular fibrosis, characterized by increased amount of connective tissue around vessels, is a hallmark for vascular disease. Ang II (angiotensin II) contributes to vascular disease and end-organ damage via promoting T-cell activation. Despite recent data suggesting the role of T cells in the progression of perivascular fibrosis, the underlying mechanisms are poorly understood.

Methods

TF (transcription factor) profiling was performed in peripheral blood mononuclear cells of hypertensive patients. CD4-targeted KLF10 (Kruppel like factor 10)-deficient (Klf10^fl/flCD4^Cre+; [TKO]) and CD4-Cre (Klf10^+/+CD4^Cre+; [Cre]) control mice were subjected to Ang II infusion. End point characterization included cardiac

SUBMITTER: Zhuang R 

PROVIDER: S-EPMC9149118 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature