Defining genomic events involved in the evolutionary trajectories of myeloma and its precursor conditions.

ABSTRACT: All patients with a diagnosis of multiple myeloma (MM) have a preceding, asymptomatic expansion of clonal plasma cells, clinically recognized as monoclonal gammopathy of undetermined significance or smoldering multiple myeloma (SMM). While most patients with monoclonal gammopathy of undetermined significance have a very small rate of progression, SMM is a widely heterogeneous condition where a fraction of patients will progress to symptomatic MM rather quickly, while others will experience an indolent clinical course. The differentiation between progressive and stable precursor condition thus represents one of the most important unmet clinical needs in the MM community. The ability to identify patients at high-risk of progression before major clonal expansion and onset of end-organ damage

SUBMITTER: Chojnacka M 

PROVIDER: S-EPMC9149131 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature