Gestational age, sex, and time affect urine biomarker concentrations in extremely low gestational age neonates.

ABSTRACT:

Background

Our understanding of the normative concentrations of urine biomarkers in premature neonates is limited.

Methods

We evaluated urine from 750 extremely low gestational age (GA) neonates without severe acute kidney injury (AKI) to determine how GA affects ten different urine biomarkers at birth and over the first 30 postnatal days. Then, we investigated if the urine biomarkers changed over time at 27, 30, and 34 weeks postmenstrual age (PMA). Next, we evaluated the impact of sex on urine biomarker concentrations at birth and over time. Finally, we evaluated if urine biomarkers were impacted by treatment with erythropoietin (Epo).

Results

We found that all ten biomarker concentrations differ at birth by GA and that some urine biomarker concentrations increase,

SUBMITTER: Askenazi DJ 

PROVIDER: S-EPMC9149147 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature