Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.

ABSTRACT: Vanilloid-subfamily TRP channels TRPV1-6 play important roles in various physiological processes and are implicated in numerous human diseases. Advances in structural biology, particularly the "resolution revolution" in cryo-EM, have led to breakthroughs in molecular characterization of TRPV channels. Structures with continuously improving resolution uncover atomic details of TRPV channel interactions with small molecules and protein-binding partners. Here, we provide a classification of structurally characterized binding sites in TRPV channels and discuss the progress that has been made by structural biology combined with mutagenesis, functional recordings, and molecular dynamics simulations toward understanding of the molecular mechanisms of ligand action. Given the similarity in structu

SUBMITTER: Yelshanskaya MV 

PROVIDER: S-EPMC9149226 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature