Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses.

ABSTRACT: How immune dysregulation affects recovery from COVID-19 infection in patients with cancer remains unclear. We analyzed cellular and humoral immune responses in 103 patients with prior COVID-19 infection, more than 20% of whom had delayed viral clearance. Delayed clearance was associated with loss of antibodies to nucleocapsid and spike proteins with a compensatory increase in functional T cell responses. High-dimensional analysis of peripheral blood samples demonstrated increased CD8⁺ effector T cell differentiation and a broad but poorly converged COVID-specific T cell receptor (TCR) repertoire in patients with prolonged disease. Conversely, patients with a CD4⁺ dominant immunophenotype had a lower incidence of prolonged disease and exhibited a deep and highly select

SUBMITTER: Lyudovyk O 

PROVIDER: S-EPMC9149241 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature