G Protein-Coupled Receptors as Potential Intercellular Communication Mediators in Trypanosomatidae.

ABSTRACT: Detection and transduction of environmental signals, constitute a prerequisite for successful parasite invasion; i.e., Leishmania transmission, survival, pathogenesis and disease manifestation and dissemination, with diverse molecules functioning as inter-cellular signaling ligands. Receptors [i.e., G protein-coupled receptors (GPCRs)] and their associated transduction mechanisms, well conserved through evolution, specialize in this function. However, canonical GPCR-related signal transduction systems have not been described in Leishmania, although orthologs, with reduced domains and function, have been identified in Trypanosomatidae. These inter-cellular communication means seem to be essential for multicellular and unicellular organism's survival. GPCRs are flexible in thei

SUBMITTER: Diaz E 

PROVIDER: S-EPMC9149261 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature