Augmented Enterocyte Damage During Candida albicans and Proteus mirabilis Coinfection.

ABSTRACT: The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and additionally interacts with residing bacteria. We investigated fungal-bacterial interactions by coinfecting enterocytes with the yeast Candida albicans and the Gram-negative bacterium Proteus mirabilis resulting in enhanced host cell damage. This synergistic effect was conserved across different P. mirabilis isolates and occurred also with non-albicans Candida species and C. albicans mutants defective in filamentation or candidalysin production. Using bacterial deletion mutants, we identified the P. mirabili

SUBMITTER: Niemiec MJ 

PROVIDER: S-EPMC9149288 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature