The Clinical Course of Early and Late Mild Cognitive Impairment.

ABSTRACT:

Introduction

Amnestic mild cognitive impairment (MCI) can be classified as either early MCI (EMCI) or late MCI (LMCI) according to the severity of memory impairment. The aim of this study was to compare the prognosis and clinical course between EMCI and LMCI.

Methods

Between January 2009 and December 2017, a total of 418 patients with MCI and 146 subjects with normal cognition were recruited from a memory clinic. All the patients received at least two series of neuropsychological evaluations each year and were categorized as either EMCI or LMCI according to Alzheimer's Disease Neuroimaging Initiative 2 (ADNI2) criteria.

Results

In total, our study included 161 patients with EMCI, 258 with LMCI, and 146 subjects with normal cognition as controls (NCs). The mean follow-

SUBMITTER: Lin SY 

PROVIDER: S-EPMC9149311 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature