Racial, Ethnic, and Sex Disparities in Nail Psoriasis Clinical Trials: A Systematic Review.

ABSTRACT:

Introduction

Nail psoriasis (NP) disproportionally affects quality of life in females versus males. Demographics of NP research cohorts are not well characterized. In this systematic review, we characterize the representation of racial/ethnic groups and women in NP randomized clinical trials (RCTs).

Methods

A systematic search of MEDLINE was performed; RCTs of NP pharmacologic treatments or cutaneous psoriasis/psoriatic arthritis with the number of NP patients described were included.

Results

Overall, 45 RCTs were analyzed, with 91.1% reporting sex, and 67.9% of participants were men. 7/41 (17%) studies reporting sex included ≥45% female participants. Of 45 RCTs, 35.6% reported race and/or ethnicity. Of the 22 studies with ≥1 US-based site, 13 (59%) reported race/ethn

SUBMITTER: Ricardo JW 

PROVIDER: S-EPMC9149505 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature