Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells.

ABSTRACT: Pluripotent cells are subject to much interest as a source of differentiated cellular material for research models, regenerative medical therapies and novel applications such as lab-cultured meat. Greater understanding of the pluripotent state and control over its differentiation is therefore desirable. The role of biomechanical properties in directing cell fate and cell behavior has been increasingly well described in recent years. However, many of the mechanisms which control cell morphology and mechanical properties in somatic cells are absent from pluripotent cells. We leveraged naturally occurring variation in biomechanical properties and expression of pluripotency genes in murine ESCs to investigate the relationship between these parameters. We observed considerable variation in a Re

SUBMITTER: Brookes O 

PROVIDER: S-EPMC9149596 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature