PINCH1 Promotes Fibroblast Migration in Extracellular Matrices and Influences Their Mechanophenotype.

ABSTRACT: Cell migration performs a critical function in numerous physiological processes, including tissue homeostasis or wound healing after tissue injury, as well as pathological processes that include malignant progression of cancer. The efficiency of cell migration and invasion appears to be based on the mechano-phenotype of the cytoskeleton. The properties of the cytoskeleton depend on internal cytoskeletal and external environmental factors. A reason for this are connections between the cell and its local matrix microenvironment, which are established by cell-matrix adhesion receptors. Upon activation, focal adhesion proteins such as PINCH1 are recruited to sites where focal adhesions form. PINCH1 specifically couples through interactions with ILK, which binds to cell matrix receptors and the

SUBMITTER: Mierke CT 

PROVIDER: S-EPMC9149598 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature