Investigation of the Binding of Lectins with Polymer Glycoconjugates and the Glycoconjugates Containing Silver Nanoparticles by Means of Optical Spectroscopy and Light Scattering.

ABSTRACT: The synthesis of glycoconjugates, lectin-specific polymers containing a carbohydrate ligand (spacered residue of N-acetyl-D-glucosamine, β-N-Gly-GlcNAc) has been carried out. Glyconanoparticles (glycol-NPs) containing a label detectable by means of spectrophotometry, silver nanoparticles, have been prepared on the basis of the glycoconjugates. Copolymers of maleic anhydride with ethylene or N-vinylpyrrolidone have been used as a carrier to introduce the carbohydrate ligand and a stabilizer of silver nanoparticles. Solutions of the glycoconjugates and the silver glyconanoparticles have been characterized by means of light scattering, UV-visible spectroscopy, and TEM. The interaction of the obtained glycoconjugates and silver glyconanoparticles with N-acetyl-D-glucosamine-specific lec

SUBMITTER: Samoilova NA 

PROVIDER: S-EPMC9149672 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature