Engineering the next generation of cell-based therapeutics.

ABSTRACT: Cell-based therapeutics are an emerging modality with the potential to treat many currently intractable diseases through uniquely powerful modes of action. Despite notable recent clinical and commercial successes, cell-based therapies continue to face numerous challenges that limit their widespread translation and commercialization, including identification of the appropriate cell source, generation of a sufficiently viable, potent and safe product that meets patient- and disease-specific needs, and the development of scalable manufacturing processes. These hurdles are being addressed through the use of cutting-edge basic research driven by next-generation engineering approaches, including genome and epigenome editing, synthetic biology and the use of biomaterials.

SUBMITTER: Bashor CJ 

PROVIDER: S-EPMC9149674 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature