Convergent copy number increase of genes associated with freshwater colonization in fishes.

ABSTRACT: Copy number variation (CNV) can cause phenotypic changes. However, in contrast to amino acid substitutions and cis-regulatory changes, little is known about the functional categories of genes in which CNV is important for adaptation to novel environments. It is also unclear whether the same genes repeatedly change the copy numbers for adapting to similar environments. Here, we investigate CNV associated with freshwater colonization in fishes, which was observed multiple times across different lineages. Using 48 ray-finned fishes across diverse orders, we identified 23 genes whose copy number increases were associated with freshwater colonization. These genes showed enrichment for peptide receptor activity, hexosyltransferase activity and unsaturated fatty acid metabolism. We further

SUBMITTER: Ishikawa A 

PROVIDER: S-EPMC9149799 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature