Therapeutic Advances and Challenges in the Management of HER2-Positive Gastroesophageal Cancers.

ABSTRACT: Gastroesophageal cancer is one of the most common cancers in the world, with a high rate of mortality. While there has been significant progress over the past decade, particularly with the addition of anti-HER2 therapies to platinum-based chemotherapy agents in the advanced setting, the prognosis remains poor and the treatment options for this disease entity remain limited. In this review, we discuss the current therapeutic landscape for HER2-positive gastroesphageal cancer and the seminal clinical trials that have shaped our approach to this disease entity. In addition, we highlight some of the challenges to the understanding and management of this disease, specifically discussing the breadth of molecular diversity and intratumoral heterogeneity of HER2 expression that impact the clinical

SUBMITTER: Chuang J 

PROVIDER: S-EPMC9149813 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature