Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite-Poly(lactic-co-glycolic acid) Composite Nanofibers.

ABSTRACT: Currently, cancer chemotherapeutic drugs still have the defects of high toxicity and low bioavailability, so it is critical to design novel drug release systems for cancer chemotherapy. Here, we report a method to fabricate electrospun drug-loaded organic/inorganic hybrid nanofibrous system for antitumor therapy applications. In this work, rod-like attapulgite (ATT) was utilized to load a model anticancer drug doxorubicin (DOX), and mixed with poly(lactic-co-glycolic acid) (PLGA) to form electrospun hybrid nanofibers. The ATT/DOX/PLGA composite nanofibers were characterized through various techniques. It is feasible to load DOX onto ATT surfaces, and the ATT/DOX/PLGA nanofibers show a smooth and uniform morphology with improved mechanical durability. Under neutral and acidic pH conditions,

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9149849 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature