Altered thalamic subregion functional networks in patients with treatment-resistant schizophrenia.

ABSTRACT:

Background

The thalamus plays a key role in filtering information and has extensive interconnectivity with other brain regions. A large body of evidence points to impaired functional connectivity (FC) of the thalamocortical pathway in schizophrenia. However, the functional network of the thalamic subregions has not been investigated in patients with treatment-resistant schizophrenia (TRS).

Aim

To identify the neural mechanisms underlying TRS, we investigated FC of thalamic sub-regions with cortical networks and voxels, and the associations of this FC with clinical symptoms. We hypothesized that the FC of thalamic sub-regions with cortical networks and voxels would differ between TRS patients and HCs.

Methods

In total, 50 patients with TRS and 61 healthy controls (HCs)

SUBMITTER: Kim WS 

PROVIDER: S-EPMC9150031 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature