Gut mucosal microbiota profiles linked to colorectal cancer recurrence.

ABSTRACT:

Background

Emerging evidence links gut microbiota to various human diseases including colorectal cancer (CRC) initiation and development. However, gut microbiota profiles associated with CRC recurrence and patient prognosis are not completely understood yet, especially in a Chinese cohort.

Aim

To investigate the relationship between gut mucosal microbiota profiles and CRC recurrence and patient prognosis.

Methods

We obtained the composition and structure of gut microbiota collected from 75 patients diagnosed with CRC and 26 healthy controls. The patients were followed up by regular examination to determine whether tumors recurred. Triplet-paired samples from on-tumor, adjacent-tumor and off-tumor sites of patients diagnosed with/without CRC recurrence were analyzed to

SUBMITTER: Huo RX 

PROVIDER: S-EPMC9150055 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature