Individual and combined effects of cannabidiol and Δ⁹-tetrahydrocannabinol on striato-cortical connectivity in the human brain.

ABSTRACT:

Background

Cannabidiol (CBD) and Δ⁹-tetrahydrocannabinol (THC) are the two major constituents of cannabis with contrasting mechanisms of action. THC is the major psychoactive, addiction-promoting, and psychotomimetic compound, while CBD may have opposite effects. The brain effects of these drugs alone and in combination are poorly understood. In particular, the striatum is implicated in the pathophysiology of several psychiatric disorders, but it is unclear how THC and CBD influence striato-cortical connectivity.

Aims

To examine effects of THC, CBD, and THC + CBD on functional connectivity of striatal sub-divisions (associative, limbic and sensorimotor).

Method

Resting-state functional Magnetic Resonance Imaging (fMRI) was used across two within-subjects, p

SUBMITTER: Wall MB 

PROVIDER: S-EPMC9150138 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature