Correlation between the fatty infiltration of paraspinal muscles and disc degeneration and the underlying mechanism.

ABSTRACT:

Background

Low back pain (LBP) is associated with lumbar disc degeneration (LDD) and fatty infiltration of paraspinal muscles. However, there are some controversies about the relationship between LDD and fatty infiltration of paraspinal muscles, and the causation of them is also not clear. Thus, we investigated whether the degree of LDD was associated with fatty infiltration of paraspinal muscles and preliminarily explored the underlying mechanism.

Methods

A retrospective study was conducted on 109 patients with chronic LBP. The degree of LDD was assessed by the Pfirrmann classification. Total muscle cross-sectional area, L4 vertebral body endplate area, and fat cross-sectional area at axial T2-weighted MRI were measured. Multifidus and lumbar disc specimens were taken from

SUBMITTER: Shi L 

PROVIDER: S-EPMC9150320 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature