Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity.

ABSTRACT:

Background

Hox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are expressed at the right time and space to determine the embryo body plan. As master transcriptional regulators, Hox proteins recognize DNA through the homeodomain (HD) and interact with a multitude of proteins, including general transcription factors and other cofactors. HD binding specificity increases by protein-protein interactions with a diversity of cofactors that outline the Hox interactome and determine the transcriptional landscape of the selected target genes. All these interactions clearly demonstrate Hox-driven transcriptional regulation, but its precise mechanism remains to be elucidated.

Results

Here we report Antennapedi

SUBMITTER: Jimenez-Mejia G 

PROVIDER: S-EPMC9150345 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature