A tensor-based bi-random walks model for protein function prediction.

ABSTRACT:

Background

The accurate characterization of protein functions is critical to understanding life at the molecular level and has a huge impact on biomedicine and pharmaceuticals. Computationally predicting protein function has been studied in the past decades. Plagued by noise and errors in protein-protein interaction (PPI) networks, researchers have undertaken to focus on the fusion of multi-omics data in recent years. A data model that appropriately integrates network topologies with biological data and preserves their intrinsic characteristics is still a bottleneck and an aspirational goal for protein function prediction.

Results

In this paper, we propose the RWRT (Random Walks with Restart on Tensor) method to accomplish protein function prediction by applying bi-random wa

SUBMITTER: Hu S 

PROVIDER: S-EPMC9150346 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature