Zero-inflated negative binomial mixed model: an application to two microbial organisms important in oesophagitis.

ABSTRACT: Altered microbial communities are thought to play an important role in eosinophilic oesophagitis, an allergic inflammatory condition of the oesophagus. Identification of the majority of organisms present in human-associated microbial communities is feasible with the advent of high throughput sequencing technology. However, these data consist of non-negative, highly skewed sequence counts with a large proportion of zeros. In addition, hierarchical study designs are often performed with repeated measurements or multiple samples collected from the same subject, thus requiring approaches to account for within-subject variation, yet only a small number of microbiota studies have applied hierarchical regression models. In this paper, we describe and illustrate the use of a hierarchical regressio

SUBMITTER: Fang R 

PROVIDER: S-EPMC9150531 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature