Applying the Addictions Neuroclinical Assessment to derive neurofunctional domains in individuals who use methamphetamine.

ABSTRACT: The Addictions Neuroclinical Assessment (ANA) was proposed as a neuroscience-informed clinical framework to understand heterogeneity in addiction encompassing dysfunction in three domains: incentive salience, negative emotionality, and executive functions. The ANA has been validated in the alcohol field but has not been extended to other substances. Thus, the objective of the current study was to replicate and extend the ANA framework to methamphetamine use disorder. Non-treatment seeking individuals (N = 185) who reported regular methamphetamine use completed a deep phenotyping battery comprising self-report and behavioral measures that assessed methamphetamine craving and emotional withdrawal symptoms, mood and anxiety symptomatology, risk-taking behaviors, working memory, attention, and

SUBMITTER: Nieto SJ 

PROVIDER: S-EPMC9150716 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature