Anti-Neuronal Nuclear Antibody 3 Autoimmunity Targets Dachshund Homolog 1.
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ABSTRACT:
SUBMITTER: Zekeridou A
PROVIDER: S-EPMC9150768 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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Anti-Neuronal Nuclear Antibody 3 Autoimmunity Targets Dachshund Homolog 1.
Zekeridou Anastasia A Yang Binxia B Lennon Vanda A VA Guo Yong Y Wu Liang L Lucchinetti Claudia F CF McKeon Andrew A Pittock Sean J SJ Flanagan Eoin P EP
Annals of neurology 20220303 5
The antigen specificity of Anti-Neuronal Nuclear Antibody-type 3 (ANNA3)-IgG is unknown. We identified Dachshund-homolog 1 (DACH1) as the ANNA3 autoantigen and confirmed it by antigen-specific assays, immunohistochemical colocalization and immune absorption experiments. Patients' median age was 63.5 years (range, 49-88); 67% were female. Neurological manifestations (information available for 30 patients) included one or more of neuropathy, 12; cognitive difficulties, 11; ataxia, 8; dysautonomia, ...[more]
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