Relative Telomere Length Is Associated With Age-Related Macular Degeneration in Women.

ABSTRACT:

Purpose

Relative telomere length (RTL) is a biomarker for physiological aging. Premature shortening of telomeres is associated with oxidative stress, which is one possible pathway that might contribute to age-related macular degeneration (AMD). We therefore aimed to investigate the association between RTL and AMD in a well-characterized group of elderly individuals.

Methods

We measured RTL in participants of the AugUR study using a multiplex quantitative PCR-based assay determining the ratio between the telomere product and a single-copy gene product (T/S ratio). AMD was assessed by manual grading of color fundus images using the Three Continent AMD Consortium Severity Scale.

Results

Among the 2262 individuals 70 to 95 years old (627 with AMD and 1635 without AMD), RT

SUBMITTER: Koller A 

PROVIDER: S-EPMC9150829 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature