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Population dynamics of Staphylococcus aureus from Northeastern Nigeria in 2007 and 2012.


ABSTRACT: The population structure of Staphylococcus aureus is changing globally but the situation regarding dominant clones in sub-Saharan Africa is not clear. We therefore assessed changes in the population structure of clinical S. aureus isolates obtained in 2007 (n = 75) and 2012 (n = 75) from Northeastern Nigeria. A reduction in resistance to penicillin, gentamicin, erythromycin and clindamycin was observed in 2012. A decrease of methicillin resistance rates (13·3% to 8·0%) was associated with the decline of the ST241 MRSA clone. The proportion of Panton-Valentine leukocidin (PVL)-positive isolates also decreased from 65·3% to 44%, and was linked with the emergence of PVL-negative ST601 clone in 2012. The significant decline in antibiotic resistance in the study area is in contrast to the worldwide trend of increasing resistance rates.

SUBMITTER: Okon KO 

PROVIDER: S-EPMC9151220 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Population dynamics of Staphylococcus aureus from Northeastern Nigeria in 2007 and 2012.

Okon K O KO   Shittu A O AO   Kudi A A AA   Umar H H   Becker K K   Schaumburg F F  

Epidemiology and infection 20131205 8


The population structure of Staphylococcus aureus is changing globally but the situation regarding dominant clones in sub-Saharan Africa is not clear. We therefore assessed changes in the population structure of clinical S. aureus isolates obtained in 2007 (n = 75) and 2012 (n = 75) from Northeastern Nigeria. A reduction in resistance to penicillin, gentamicin, erythromycin and clindamycin was observed in 2012. A decrease of methicillin resistance rates (13·3% to 8·0%) was associated with the de  ...[more]

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