Pyocyanin biosynthesis protects Pseudomonas aeruginosa from nonthermal plasma inactivation.

ABSTRACT: Pseudomonas aeruginosa is an important opportunistic human pathogen, which raises a worldwide concern for its increasing resistance. Nonthermal plasma, which is also called cold atmospheric plasma (CAP), is an alternative therapeutic approach for clinical infectious diseases. However, the bacterial factors that affect CAP treatment remain unclear. The sterilization effect of a portable CAP device on different P. aeruginosa strains was investigated in this study. Results revealed that CAP can directly or indirectly kill P. aeruginosa in a time-dependent manner. Scanning electron microscopy and transmission electron microscope showed negligible surface changes between CAP-treated and untreated P. aeruginosa cells. However, cell leakage occurred during the CAP process with increased bacterial

SUBMITTER: Zhou H 

PROVIDER: S-EPMC9151332 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature