Subcutaneous adipose tissue expansion mechanisms are similar in early and late onset overweight/obesity.

ABSTRACT:

Background/objective

The development of overweight/obesity associates with alterations in white adipose tissue (WAT) cellularity (fat cell size/number) and lipid metabolism, in particular lipolysis. If these changes differ between early/juvenile (EOO < 18 years of age) or late onset overweight/obesity (LOO) is unknown and was presently examined.

Subjects/methods

We included 439 subjects with validated information on body mass index (BMI) at 18 years of age. Using this information and current BMI, subjects were divided into never overweight/obese (BMI < 25 kg/m²), EOO and LOO. Adipocyte size, number, morphology (size in relation to body fat) and lipolysis were determined in subcutaneous abdominal WAT. Body composition and WAT distribution was assessed by dual-X-ray

SUBMITTER: Arner P 

PROVIDER: S-EPMC9151387 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature