Tissue losses and metabolic adaptations both contribute to the reduction in resting metabolic rate following weight loss.

ABSTRACT:

Objective

To characterize the contributions of the loss of energy-expending tissues and metabolic adaptations to the reduction in resting metabolic rate (RMR) following weight loss.

Methods

A secondary analysis was conducted on data from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy study. Changes in RMR, body composition, and metabolic hormones were examined over 12 months of calorie restriction in 109 individuals. The contribution of tissue losses to the decline in RMR was determined by weighing changes in the size of energy-expending tissues and organs (skeletal muscle, adipose tissue, bone, brain, inner organs, residual mass) assessed by dual-energy X-ray absorptiometry with their tissue-specific metabolic rates. Metabolic adaptations wer

SUBMITTER: Martin A 

PROVIDER: S-EPMC9151388 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature