Comparison of linear and volumetric criteria for the determination of therapeutic response in dogs with intracranial gliomas.

ABSTRACT:

Background

Brain tumor therapeutic responses can be quantified from magnetic resonance images (MRI) using 1- (1D) and 2-dimensional (2D) linear and volumetric methods, but few studies in dogs compare these techniques.

Hypotheses

Linear methods will be obtained faster, but have less agreement than volumetric measurements. Therapeutic response agreement will be highest with the total T2W tumor volumetric (TTV) method. Therapeutic response at 6-weeks will correlate with overall survival (OS).

Animals

Forty-six dogs with intracranial gliomas.

Methods

Prospective study. Three raters measured tumors using 1D and 2D linear, TTV, and contrast-enhancing volumetric (CEV) techniques on 143 brain MRI to determine agreement between methods, define therapeutic responses, and

SUBMITTER: Garcia Mora JK 

PROVIDER: S-EPMC9151452 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature