Circulating renin-angiotensin-aldosterone system activity in cats with systemic hypertension or cardiomyopathy.

ABSTRACT:

Background

Activity of the circulating renin-angiotensin-aldosterone system (RAAS) has not been comprehensively characterized in cats with systemic hypertension (SH) or cardiomyopathy (CM), and the effects of furosemide or amlodipine treatment on the RAAS have not been fully evaluated in cats.

Hypothesis/objectives

To document RAAS activity in cats with SH or CM compared to healthy cats and determine how RAAS profiles change with furosemide or amlodipine treatment.

Animals

Sixty-six client-owned cats: 15 with SH (7 amlodipine-treated, 8 untreated), 17 with advanced CM (7 furosemide-treated, 10 not furosemide-treated), and 34 healthy cats.

Methods

Equilibrium concentrations of RAAS peptides and aldosterone were quantified in serum samples by liquid chromatograph

SUBMITTER: Ward JL 

PROVIDER: S-EPMC9151484 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature