Prevalence of clinical signs and factors impacting expression of myosin heavy chain myopathy in Quarter Horse-related breeds with the MYH1^E321G mutation.

ABSTRACT:

Background

The prevalence of clinical signs and factors triggering muscle atrophy and rhabdomyolysis associated with an MYH1^E321G mutation in Quarter Horses and related breeds (QH) remain poorly understood.

Hypothesis/objectives

Determine the prevalence and potential triggers of atrophy and stiffness in horses homozygous reference (N/N), heterozygous (My/N), and homozygous (My/My) for the MYH1^E321G mutation.

Animals

Two-hundred seventy-five N/N, 100 My/N, and 10 My/My QH.

Methods

A retrospective case-control study using a closed-ended questionnaire completed by clients of the Veterinary Genetics Laboratory at the University of California, Davis. History of clinical signs, disease, vaccination and performance were analyzed by genotype using

SUBMITTER: Valberg SJ 

PROVIDER: S-EPMC9151494 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature