Activity of the adrenomedullin system to personalise post-discharge diuretic treatment in acute heart failure.

ABSTRACT:

Background

Quantifying the activity of the adrenomedullin system might help to monitor and guide treatment in acute heart failure (AHF) patients. The aims were to (1) identify AHF patients with marked benefit or harm from specific treatments at hospital discharge and (2) predict mortality by quantifying the adrenomedullin system activity.

Methods

This was a prospective multicentre study. AHF diagnosis and phenotype were centrally adjudicated by two independent cardiologists among patients presenting to the emergency department with acute dyspnoea. Adrenomedullin system activity was quantified using the biologically active component, bioactive adrenomedullin (bio-ADM), and a prohormone fragment, midregional proadrenomedullin (MR-proADM). Bio-ADM and MR-proADM concentrations w

SUBMITTER: Kozhuharov N 

PROVIDER: S-EPMC9151518 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature