Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure.

ABSTRACT:

Introduction

Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac disease, leading to a reduction in β-oxidation of fatty acids and an increased dependence upon glycolysis.

Objectives

This study aimed to evaluate whether a shift in substrate use occurs in canine patients with MMVD; a naturally occurring model of human disease.

Methods

Client-owned dogs were longitudinally evaluated at a research clinic in London, UK and paired serum samples were selected from visits when patients were in ACVIM stage B1: asymptomatic disease without cardiomegaly, and stage C: HF.

SUBMITTER: Wilshaw J 

PROVIDER: S-EPMC9151558 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature