Dataset Information

Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation.

ABSTRACT:

Background

Despite the multitude of clinical manifestations of post-acute sequelae of SARS-CoV-2 infection (PASC), studies applying statistical methods to directly investigate patterns of symptom co-occurrence and their biological correlates are scarce.

Methods

We assessed 30 symptoms pertaining to different organ systems in 749 adults (age = 55 ± 14 years; 47% female) during in-person visits conducted at 6-11 months after hospitalization due to coronavirus disease 2019 (COVID-19), including six psychiatric and cognitive manifestations. Symptom co-occurrence was initially investigated using exploratory factor analysis (EFA), and latent variable modeling was then conducted using Item Response Theory (IRT). We investigated associations of latent variable severity with objective indices of persistent physical disability, pulmonary and kidney dysfunction, and C-reactive protein and D-dimer blood levels, measured at the same follow-up assessment.

Results

The EFA extracted one factor, explaining 64.8% of variance; loadings were positive for all symptoms, and above 0.35 for 16 of them. The latent trait generated using IRT placed fatigue, psychiatric, and cognitive manifestations as the most discriminative symptoms (coefficients > 1.5, p < 0.001). Latent trait severity was associated with decreased body weight and poorer physical performance (coefficients > 0.240; p ⩽ 0.003), and elevated blood levels of C-reactive protein (coefficient = 0.378; 95% CI 0.215-0.541; p < 0.001) and D-dimer (coefficient = 0.412; 95% CI 0.123-0.702; p = 0.005). Results were similar after excluding subjects with pro-inflammatory comorbidities.

Conclusions

Different symptoms that persist for several months after moderate or severe COVID-19 may unite within one latent trait of PASC. This trait is dominated by fatigue and psychiatric symptoms, and is associated with objective signs of physical disability and persistent systemic inflammation.

SUBMITTER: Busatto GF

PROVIDER: S-EPMC9151630 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation.

Busatto Geraldo F GF de Araujo Adriana Ladeira AL Castaldelli-Maia João Mauricio JM Damiano Rodolfo Furlan RF Imamura Marta M Guedes Bruno F BF de Rezende Pinna Fabio F Sawamura Marcio Valente Yamada MVY Mancini Márcio C MC da Silva Katia R KR Garcia Michelle L ML Sumita Nairo N Brunoni Andre Russowsky AR da Silva Duarte Alberto J AJ Burdmann Emmanuel A EA Kallas Esper G EG Cerri Giovanni G GG Nitrini Ricardo R Bento Ricardo F RF Rocha Vanderson Geraldo VG de Souza Heraldo Possolo HP Miguel Euripedes C EC de Carvalho Carlos R R CRR Forlenza Orestes V OV Batistella Linamara Rizzo LR

Psychological medicine 20220506 12

<h4>Background</h4>Despite the multitude of clinical manifestations of post-acute sequelae of SARS-CoV-2 infection (PASC), studies applying statistical methods to directly investigate patterns of symptom co-occurrence and their biological correlates are scarce.<h4>Methods</h4>We assessed 30 symptoms pertaining to different organ systems in 749 adults (age = 55 ± 14 years; 47% female) during in-person visits conducted at 6-11 months after hospitalization due to coronavirus disease 2019 (COVID-19) ...[more]

PMID: 35521752

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Dataset Information

Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation.

Background

Methods

Results

Conclusions

Publications

Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation.

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