Chord: an ensemble machine learning algorithm to identify doublets in single-cell RNA sequencing data.
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ABSTRACT:
SUBMITTER: Xiong KX
PROVIDER: S-EPMC9151659 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Chord: an ensemble machine learning algorithm to identify doublets in single-cell RNA sequencing data.
Xiong Ke-Xu KX Zhou Han-Lin HL Lin Cong C Yin Jian-Hua JH Kristiansen Karsten K Yang Huan-Ming HM Li Gui-Bo GB
Communications biology 20220530 1
High-throughput single-cell RNA sequencing (scRNA-seq) is a popular method, but it is accompanied by doublet rate problems that disturb the downstream analysis. Several computational approaches have been developed to detect doublets. However, most of these methods may yield satisfactory performance in some datasets but lack stability in others; thus, it is difficult to regard a single method as the gold standard which can be applied to all types of scenarios. It is a difficult and time-consuming ...[more]
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