Genetic diversity of E6, E7 and the long control region in human papillomavirus type 16 variants in Beijing, China.

ABSTRACT:

Background

High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. The progression from initial infection to cervical cancer has been linked to properties of the viral sequences. However, the distribution of HPV16 variants among Chinese women has not been extensively addressed and the role of HPV16 variants in the risk of cervical carcinogenesis remains poorly understood.

Methods

HPV16 positive cervical exfoliated cell samples were collected from 249 women living in Beijing, China. PCR products from two fragments of E6-E7 and LCR of HPV16 in these samples were sequenced and analyzed.

Results

Lineage A was found in the subjects, including A1, A2, A3 and A4 sublineages. Based on the HPV16 reference sequences, 26 nucleotide mutations of A4 su

SUBMITTER: Wang J 

PROVIDER: S-EPMC9151740 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature