Stochastic expression of invasion genes in Plasmodium falciparum schizonts.

ABSTRACT: Genetically identical cells are known to exhibit differential phenotypes in the same environmental conditions. These phenotypic variants are linked to transcriptional stochasticity and have been shown to contribute towards adaptive flexibility of a wide range of unicellular organisms. Here, we investigate transcriptional heterogeneity and stochastic gene expression in Plasmodium falciparum by performing the quasilinear multiple annealing and looping based amplification cycles (MALBAC) based amplification and single cell RNA sequencing of blood stage schizonts. Our data reveals significant transcriptional variations in the schizont stage with a distinct group of highly variable invasion gene transcripts being identified. Moreover, the data reflects several diversification processes includin

SUBMITTER: Tripathi J 

PROVIDER: S-EPMC9151791 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature