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Nationwide surveillance study of human astrovirus infections in an Italian paediatric population.


ABSTRACT: The study investigated the genetic diversity of human astroviruses (HAstVs) detected in children hospitalized with gastroenteritis in Italy in 2008-2009. A total of 1321 faecal samples were collected in Parma (northern Italy), Bari (southern Italy), and Palermo (Sicily) and screened for the presence of HAstVs. RT-PCR amplification of a portion at the 5'-end of ORF2 allowed the detection of HAstVs in 3·95% of the patients. Four different genotypes (HAstV-1, HAstV-2, HAstV-4, HAstV-5) were found to be circulating during the study period, with HAstV-1 being the predominant type. Interestingly, a novel lineage, proposed as HAstV-2d, was found to have emerged in Parma in 2009. Investigating the genetic variability of HAstVs will be important for understanding the epidemiological trends and evolution of these viruses.

SUBMITTER: DE Grazia S 

PROVIDER: S-EPMC9151877 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Nationwide surveillance study of human astrovirus infections in an Italian paediatric population.

DE Grazia S S   Martella V V   Chironna M M   Bonura F F   Tummolo F F   Calderaro A A   Moschidou P P   Giammanco G M GM   Medici M C MC  

Epidemiology and infection 20120517 3


The study investigated the genetic diversity of human astroviruses (HAstVs) detected in children hospitalized with gastroenteritis in Italy in 2008-2009. A total of 1321 faecal samples were collected in Parma (northern Italy), Bari (southern Italy), and Palermo (Sicily) and screened for the presence of HAstVs. RT-PCR amplification of a portion at the 5'-end of ORF2 allowed the detection of HAstVs in 3·95% of the patients. Four different genotypes (HAstV-1, HAstV-2, HAstV-4, HAstV-5) were found t  ...[more]

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