A noble extended stochastic logistic model for cell proliferation with density-dependent parameters.

ABSTRACT: Cell proliferation often experiences a density-dependent intrinsic proliferation rate (IPR) and negative feedback from growth-inhibiting molecules in culture media. The lack of flexible models with explanatory parameters fails to capture such a proliferation mechanism. We propose an extended logistic growth law with the density-dependent IPR and additional negative feedback. The extended parameters of the proposed model can be interpreted as density-dependent cell-cell cooperation and negative feedback on cell proliferation. Moreover, we incorporate further density regulation for flexibility in the model through environmental resistance on cells. The proposed growth law has similarities with the strong Allee model and harvesting phenomenon. We also develop the stochastic analog of the dete

SUBMITTER: Roy T 

PROVIDER: S-EPMC9151920 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature